Endocrine Abstracts

Background: The 5-year survival rate for patients with unresectable, metastatic pancreatic neuroendocrine tumors (pNETs) remains less than 30%, emphasizing the need for new and effective treatment options for patients with advanced pNETs. Notch1 signaling is a critical cell-cell communication pathway responsible for regulating differentiation, cell fate determination, and epithelial-mesenchymal transition (EMT). Notch1 plays a critical role in the differentiation state of NE c...

Colon polyps represent a frequent complication of acromegaly. Knowledge about prevalence and risk factors of polyps’ recurrence in acromegalic patients is still limited. The current retrospective study aimed at investigating polyps’ prevalence and recurrence risk factors in acromegalic patients. One hundred and forty-three patients (73 males, 70 females) referring to “Federico II” university diagnosed with acromegaly from 2000 to 2022 who underwent at least...

Background and aims: Hyperglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hyperglycemia have not been extensively studied. The aim of this study was to assess the impact of level of fasting plasma glucose, HbA1c on the platelet activity, the physiological anticoagulant activity and fibrinolysis in patients with Diabetes Mellitus type 1 (DM1).Ma...

Background and aims: In 2005, experts from the IDF assigned the risk of developing coronary heart disease in patients with type 1 diabetes mellitus (DM1) at age of 30 and over or patients with DM1 with kidney damage equal to the patients with type 2 diabetes mellitus. The need for a non-invasive preclinical marker for identifying patients with the increased risk of cardiovascular disease is obvious. The assessment of arterial stiffness can play a role of such marker. The aim o...

11β-hydroxylase deficiency is the second most frequent cause of congenital adrenal hyperplasia (CAH), corresponding to approximately 5% of cases., and caused by inactivating mutations in the CYP11B1 gene. We aimed to describe four new cases from two different families with a clinical diagnosis of 11β-hydroxylase deficiency. Family 1: Two siblings born from consanguineous parents. A 31-year-old (yo) woman presented at 5 yo with genital ambiguity (Prader II), ...

Introduction: Ectopic adrenocorticotropic hormone (ACTH) production by the pulmonary neuroendocrine tumour (p-NET) is rare, and is considered an aggressive variant of carcinoid tumours with poor prognosis.Case presentation: 59-year-old male with fast progressing generalized fatigue, abdominal discomfort, and diarrhea was hospitalized in gastroenterology unit of Hospital of Lithuanian University of Health Sciences, Kauno klinikos (HLUHS KK). Digestive tra...

Background: Diabetes is the most prevalent chronic metabolic disorder in children and adolescents, and incidence rates for both type-1 and type-2 diabetes are increasing worldwide. In recent years, the number of patients with type 1 diabetes is increasing mainly due to children under 5-years-old.Objective: To study the epidemiological indicators of T1DM among children of the Republic of Armenia (RA) from 2007 to 2016. Methods: Retrospective analysis of t...

Introduction: Thyroid cancer is a major public health problem, and fine-needle biopsy is an established method of its early detection. However, there are still some controversy about the indication for BACC depending on the clinical data and the results of diagnostic imaging. An important role is also played by economic criteria, including socially acceptable, so-called equitable cost of obtaining additional year of life, which in our country is determined to three times the a...

Background and aim: Up to now, there is paucity of studies concerning health status in adults with congenital adrenal hyperplasia (CAH). We aimed to examine a group of adult CAH patients from different Czech centers.Methods: Serum lipids, glucose, blood pressure and anhtropometrics were compared in 31 males and 71 females with CAH 21-hydroxylase deficiency and in healthy population from Czech post-MONICA study (1% random population sample).<p class="...

Aim: Evaluation of pressure pain threshold and β-endorphin plasma level in lean women with polycystic ovary syndrome (PCOS) and healthy controls. The associations between β- endorphins and pressure pain threshold were also investigated.Materials and methods: In 48 lean women with polycystic ovary syndrome and 38 lean women without this disorder plasma β-endorphins and pressure pain thresholds were measured.Results: T...